Snapshot A 66-year-old man presents to his primary care physician for generalized weakness and episodes of lightheadedness. He says that his symptoms began approximately a few weeks ago after there was a change in his blood pressure medications. Medical history is significant for hypertension and newly diagnosed benign prostatic hyperplasia. After being in the supine position for 5 minutes, he was asked to stand, and a blood pressure was obtained 3 minutes after standing. There was a 23 mmHg decrease in systolic blood pressure. Introduction Clinical definition login to view 3 more bullets Epidemiology Incidence login to view 2 more bullets Risk factors login to view 3 more bullets Etiology Autonomic failure Volume depletion/dehydration login to view 2 more bullets Medications (e.g., terazosin) Pathophysiology login to view 9 more bullets Presentation Symptoms login to view 4 more bullets Studies Blood pressure measurements login to view 4 more bullets Electrocardiogram login to view 1 more bullet Treatment Conservative login to view 4 more bullets Medical login to view 3 more bullets Complications There is an increased cardiovascular and all-cause mortality