Snapshot A 40-year-old woman presents to her physician’s office for dyspnea on exertion and exercise intolerance. She states that her symptoms seem to be worsening over time. Her medical history includes breast cancer. A year prior to presentation, she had completed multiple rounds of chemotherapy and radiation therapy for her breast cancer. Echocardiogram shows diastolic dysfunction with preserved systolic function. Introduction Clinical definition login to view 1 more bullet Epidemiology Incidence login to view 1 more bullet Demographics login to view 1 more bullet Etiology Pathogenesis login to view 3 more bullets Post-radiation fibrosis Loffler endocarditis login to view 2 more bullets Endocardial fibroelastosis in children and young adults Amyloidosis Sarcoidosis Scleroderma Neoplasia Hemochromatosis login to view 1 more bullet Radiation therapy login to view 1 more bullet Presentation Symptoms login to view 5 more bullets Physical exam login to view 8 more bullets Imaging Radiography login to view 7 more bullets Echocardiogram login to view 6 more bullets Studies Electrocardiogram login to view 2 more bullets Endomyocardial biopsy login to view 6 more bullets Making the diagnosis login to view 1 more bullet Differential Constrictive pericarditis login to view 5 more bullets Dilated cardiomyopathy login to view 3 more bullets Treatment Management approach login to view 1 more bullet Medical login to view 3 more bullets Non-operative login to view 3 more bullets Operative login to view 3 more bullets Complications Heart failure Arrhythmias Prognosis Poor prognosis without treatment Progressive over time