Snapshot A 62-year-old woman presents to her physician for painless swelling of her ankle. She reports a history of diabetic neuropathy and regularly sees a podiatrist. Physical exam reveals a non-tender, swollen, and erythematous ankle joint with decreased range of motion. Laboratory studies show a normal leukocyte count and normal inflammatory markers. Introduction Clinical definition login to view 1 more bullet Epidemiology demographics login to view 1 more bullet location login to view 3 more bullets risk factors login to view 8 more bullets Etiology Pathogenesis login to view 3 more bullets Associated conditions login to view 8 more bullets Presentation Symptoms login to view 1 more bullet Physical exam login to view 6 more bullets Imaging Radiography login to view 9 more bullets Magnetic resonance imaging (MRI) with gadolinium login to view 4 more bullets Bone scintigraphy (typically, technetium-99m-labeled methylene diphosphonate followed by indium-labeled leukocyte scintigraphy) login to view 5 more bullets Studies Labs login to view 1 more bullet Making the diagnosis login to view 1 more bullet Differential Cellulitis login to view 2 more bullets Osteomyelitis login to view 3 more bullets Treatment Conservative login to view 6 more bullets Operative login to view 4 more bullets Complications Spontaneous fractures Osteomyelitis