Snapshot A 6-year-old girl presents to the pediatrician with her mother due to the presence of vaginal bleeding. The mother said she began menarche at 14 years of age and the patient's older sister at 15. The mother is in a healthy relationship with her husband and reports that the patient has been complaining of bone pain and stiffness in her legs. On physical exam, the patient is happy, playful, and conversational. There is tenderness to palpation in her bilateral lower extremities, as well as a hyperpigmented spot with ragged edges. There is mild blood in the vaginal introitus with no evidence of vaginal trauma. Introduction Clinical definition login to view 6 more bullets Epidemiology Incidence login to view 1 more bullet Demographics login to view 1 more bullet Etiology Pathogenesis login to view 1 more bullet Genetics login to view 6 more bullets Presentation Symptoms login to view 5 more bullets Physical exam login to view 4 more bullets Imaging Radiographs login to view 6 more bullets Studies Labs login to view 1 more bullet Differential Neurofibromatosis type I login to view 1 more bullet Treatment There are no specific treatments for McCune-Albright syndrome login to view 1 more bullet Complications Increased risk for fracture