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  • Snapshot
  • Introduction
    • One of 7 medications used for asthma aimed to reduce inflammation and obstruction
      • corticosteroids
      • β-agonists
      • muscarinic agonists
      • methylxanthines
      • cromolyn
      • antileukotrienes
      • omalizumab
  • Omalizumab
    • Mechanism of action
      • monoclonal antibody against IgE
        • binds and inhibits free serum IgE
      • IgE is involved in bronchoconstriction and recruitment of inflammatory cells to combat allergens
        • therefore, omalizumab lessens these responses
    • Clinical uses
      • moderate-to-severe persistent asthma
        • symptoms must be inadequately controlled on inhaled corticosteroids
        • must have IgE-mediated allergy to at least 1 year-round allergen, proven by allergen skin test
        • must have elevated serum IgE levels
      • chronic idiopathic urticaria
    • Adverse effects
      • hypersensitivity reactions
        • local injection site reactions
        • urticaria
        • anaphylaxis
          • 1-2 out of 1000
      • serum sickness-like reaction
        • very rare, only case reports
        • treatment
          • discontinue omalizumab and give antihistamines
          • glucocorticoids for severe symptoms
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