Snapshot A 2-month-old female baby is seen in the emergency room with frequent nosebleeds and bruising. Her birth history is unremarkable, except for delayed separation of the umbilical cord. On physical exam, there is some blood in his nose. Lab results show normal PT and PTT but increased bleeding time. Her platelets come back at a normal range. Peripheral blood smear shows no clumping of platelets. Introduction Impaired platelet aggregation from genetic deficiency of GpIIb/IIIa Key lab finding login to view 2 more bullets ETIOLOGY Pathogenesis login to view 5 more bullets Genetics login to view 1 more bullet Associated conditions login to view 6 more bullets Presentation Symptoms from platelet abnormalities login to view 4 more bullets STUDIES ↑ bleeding time Normal PT/PTT Complete blood count login to view 2 more bullets Peripheral blood smear login to view 1 more bullet Differential Diagnosis Bernard-Soulier (↓ platelet count, ↑ bleeding time, and ↓ GpIb) ITP (↓ platelet count, ↑ bleeding time, and anti-GpIIb/IIIa antibodies) TTP (↓ platelet count, ↑ bleeding time, and defective/deficient ADAMTS13) Treatment Prevention login to view 1 more bullet Platelet transfusions login to view 1 more bullet No clear evidence but options are login to view 2 more bullets Supportive care login to view 1 more bullet Complications Uncontrolled bleeding Prognosis Good with supportive care Generally, bleeding decreases with age