Please rate topic.
Average 4.4 of 9 Ratings
A 27-year-old female presents to the emergency department with complaints of acute-onset fatigue, blurred vision, and rash earlier today. Her husband rushed her to emergency department when he noted that she was exhibiting changes in her mental status and had trouble speaking. Her vital signs are as follows: T 38.4, HR 87, BP 110/85, RR 14, and SpO2 96%. Physical examination reveals petechiae, pallor, and left upper extremity weakness. Work-up reveals Hgb 8.5 g/dL, platelets 22,000 cells/uL, normal PT/INR and PTT, absent fibrin split products, elevated fibrinogen, a negative Coombs test, 3.7 mg/dL creatinine, 3.8 mg/dL indirect bilirubin, and LDH 1000 IU/L. Which of the following would be expected on a peripheral blood smear from this patient?
Select Answer to see Preferred Response
A 45-year-old man is brought to the emergency room by his wife because he has been acting confused for the past day. He is febrile, with an oral temperature of 103.6 deg F; vital signs are otherwise stable. His physical exam is significant for the finding shown in Figure A; he has never noticed lesions like these before. He also has subtle right-sided weakness affecting upper and lower extremities. Labs reveal: hemoglobin 7.0 g/dL, hematocrit 21%, white blood count of 10.2 x 10^3 µL, and platelet count of 20 x 10^3 per µL. PT/INR and PTT are normal. A peripheral blood smear is shown in Figure B. What is the most likely diagnosis?
Idiopathic thrombocytopenic purpura
Disseminated intravascular coagulation
Thrombotic thrombocytopenic purpura
Hemolytic uremic syndrome