Snapshot A 42-year-old man presents to his primary care physician's office for easy bruising and gingival bleeding. He reports his symptoms began one day prior to presentation and has never occurred before. Medical history is significant for a recently diagnosed hepatitis C infection. On physical exam, there is mild bleeding of the gums. There are petechiae throughout the chest, arms, and legs. There is no evidence of splenomegaly on abdominal exam. A complete blood count is significant for a platelet count of 24,000/μL and peripheral blood smear demonstrates enlarged platelets. He is started on corticosteroids. Introduction Clinical definition login to view 1 more bullet Epidemiology Demographics login to view 1 more bullet Etiology Primary ITP login to view 1 more bullet Secondary ITP login to view 9 more bullets Pathogenesis login to view 2 more bullets Classification Primary immune thrombocytopenia (ITP) login to view 1 more bullet Secondary ITP login to view 1 more bullet Presentation Symptoms login to view 4 more bullets Physical exam login to view 4 more bullets Studies CBC and platelet count Differential Hypersplenism login to view 2 more bullets Liver disease login to view 3 more bullets Microangiopathic hemolytic process (e.g., thrombotic thrombocytopenic purpura) login to view 2 more bullets Diagnosis Making the diagnosis login to view 8 more bullets Treatment Conservative login to view 3 more bullets Medical login to view 6 more bullets Operative login to view 3 more bullets Complications Fatal hemorrhage