Snapshot A 40-year-old woman with systemic lupus erythematosus presents for evaluation of recurrent deep venous thromboses. In the past year, she has had 5 events. On further questioning, she also reveals a history of having 2 spontaneous abortions at > 10 weeks gestation. Today, her physical exam is unremarkable. Blood testing reveals a positive antinuclear antibody and lupus anticoagulant. She is started on anticoagulation. Introduction Clinical definition login to view 1 more bullet Epidemiology Incidence login to view 1 more bullet Demographics login to view 2 more bullets Risk factors login to view 7 more bullets ETIOLOGY Pathogenesis login to view 2 more bullets Associated conditions login to view 3 more bullets Presentation Symptoms login to view 7 more bullets Physical exam login to view 2 more bullets Studies Labs login to view 13 more bullets Differential Factor V Leiden mutation login to view 2 more bullets Antithrombin deficiency login to view 2 more bullets DIAGNOSIS Based on clinical presentation and laboratory studies Diagnostic criteria includes ≥1 clinical and ≥1 laboratory criteria login to view 9 more bullets Treatment Medical login to view 9 more bullets Complications Fetal loss Stroke Prognosis Risk of recurrence is high