Please confirm topic selection

Are you sure you want to trigger topic in your Anconeus AI algorithm?

Please confirm action

You are done for today with this topic.

Would you like to start learning session with this topic items scheduled for future?

Updated: Dec 29 2021

Interventional Studies

  • Overview
    • Interventional studies are prospective studies designed to evaluate the direct impact of therapies or preventative measures by assigning subjects to intervention groups
    • 2 types of interventional studies
      • clinical trials
        • individuals assigned to competing intervention groups
      • community interventions
        • assigment at the group level (e.g. one community receives fluoridinated water and one does not)
    • Highest quality if
      • randomized
      •  controlled
      • double-blinded
  • Clinical Drug Trials
    • 4 phases for clinical trials evaluating new drugs
      • phase I
        • small number of healthy subjects (< 100)
        • purpose
          • safety and dosage
      • phase II
        • small number of diseased patients (100-300)
        • purpose
          • efficacy and side effects
      • phase III
        • large number of diseased patients (> 1,000)
        • purpose
          • effectiveness and monitoring of adverse reactionscompare to standard of care
      • phase IV 
        • post-marketing surveillance
        • purpose
          • detects rare or long-term adverse effects
  • Factorial Design
    • Randomizes patients into different interventions with 2 or more variables being studied in each intervention 
      • allows researchers to study the effects of multiple independent variables independently and mutually on a dependent variable
        • e.g., group 1 studies effect of treatments A+B on variable X, group 2 studies effects of A alone, group 3 studies effect of B alone, and group 4 is the control group receiving no treatment
  • Crossover design
    • Participants alternate receiving intervention and placebo
    • Participants act as own controls
      •  improves power and precision of study
      • need washout period between interventions
      • all patients receive intervention
1 of 0
Private Note

Attach Treatment Poll
Treatment poll is required to gain more useful feedback from members.
Please enter Question Text
Please enter at least 2 unique options
Please enter at least 2 unique options
Please enter at least 2 unique options