Snapshot A 14-year-old boy with past medical history of cystic fibrosis presents to his pulmonologist for a new cough. He reports that for the past few weeks, he has been coughing up brown sputum more and experiencing low-grade fevers. A recent chest radiograph showed a left lower lobe consolidation, and he completed a course of antibiotics without improvement. He also recently underwent testing for tuberculosis, which was all negative. On physical exam, there is wheezing and crackles bilaterally. A chest computed tomography (CT) shows central bronchiectasis and a skin test for Aspergillus causes a wheal 5 mm in diameter to form on his skin. Introduction Clinical definition login to view 1 more bullet Epidemiology Demographics login to view 2 more bullets Risk factors login to view 2 more bullets ETIOLOGY Pathogenesis login to view 2 more bullets Associated conditions login to view 6 more bullets Presentation Symptoms login to view 7 more bullets Physical exam login to view 3 more bullets imaging Chest radiograph login to view 3 more bullets Chest computed tomography (CT) login to view 3 more bullets Studies Diagnostic testing login to view 7 more bullets Differential Tuberculosis login to view 3 more bullets DIAGNOSIS Diagnostic criteria login to view 5 more bullets Treatment Management approach login to view 1 more bullet First-line login to view 1 more bullet Second-line login to view 3 more bullets Other treatments login to view 2 more bullets Complications Respiratory failure Pulmonary hypertension Pneumothorax