Overview Snapshot A 39-year-old woman presents to her primary care physician's office due to pain and numbness in her hand. The patient reports that the pain is worse at night and when her hand is outstretched; to relieve the pain she shakes her hand or places it under warm running water. She says her symptoms mainly affect the first 3 digits of her hand. She denies any recent injury to or pain in the hand or neck. On physical exam, she has normal range of motion of the neck and arm. She has 2+ bilateral biceps, triceps, and brachioradialis reflexes. She has a positive Phalen and Tinel test. Introduction Clinical definition compressive median nerve neuropathy Epidemiology demographics bimodal distribution 50-60 and 70-80 years of age risk factors female gender obesity pregnancy hypothyroidism rheumatoid arthritis dialysis-related amyloidosis dialysisrelated amyloidosis repetitive use of the hand or wrist Etiology increased pressure within the carpal tunnel Pathoanatomy normal anatomy the carpal tunnel contains digital flexor tendons flexor pollicis longus tendon median nerve pathology synovial noninflammatory fibrosis and thickening leads to median nerve compression (most common) compression leads to microvascular insufficiency causing ischemic damage to the nerve Prognosis in mild-to-moderate cases, there is spontaneous resolution or response to conservative therapy Presentation Symptoms pain or paresthesia in the median nerve distribution median nerve distribution the first 3 digits and radial half of 4th digit symptoms typically worse at night weakness or hand clumsiness Physical exam provoking tests Phalen test patients flexes palm at the wrist pain and/or paresthesia in the median nerve distribution is a positive test Tinel test percussion over the course of the median nerve pain and/or paresthesia in the median nerve distribution is a positive test Studies Making the diagnosis the diagnosis can be clinically made; however, it is confirmed by nerve conduction studies Nerve conduction studies indication may be used when contemplating surgical decompression Electromyogram indication typically used to exclude other etiologies such as polyneuropathy plexopathy radiculopathy Differential Cervical radiculopathy compressing C5-C6 distinguishing factor patients have neck pain, worsening symptoms with head movement, and pain radiation to the shoulders and arm patients also have reduced biceps, brachioradialis, and triceps reflex Treatment Conservative splinting indication to improve mild carpal tunnel syndrome symptoms Medical corticosteroid (oral or injection) indication to improve mild carpal tunnel syndrome symptoms Operative surgical decompression indication for severe median nerve injury reflected by nerve conduction studies (e.g., severe axonal degeneration) or needle electromyography Complications Rare
QUESTIONS 1 of 5 1 2 3 4 5 Previous Next Lab Values Blood Hematologic Cerebrospinal Sweat, Urine, and BMI Blood, Plasma, Serum Reference Range ALT 8-20 U/L Amylase, serum 25-125 U/L AST 8-20 U/L Bilirubin, serum (adult) Total // Direct 0.1-1.0 mg/dL // 0.0-0.3 mg/dL Calcium, serum (Ca2+) 8.4-10.2 mg/dL Cholesterol, serum Rec: < 200 mg/dL Cortisol, serum 0800 h: 5-23 μg/dL //1600 h: 3-15 μg/dL 2000 h: ≤ 50% of 0800 h Creatine kinase, serum Male: 25-90 U/LFemale: 10-70 U/L Creatinine, serum 0.6-1.2 mg/dL Electrolytes, serum Sodium (Na+) 136-145 mEq/L Chloride (Cl-) 95-105 mEq/L Potassium (K+) 3.5-5.0 mEq/L Bicarbonate (HCO3-) 22-28 mEq/L Magnesium (Mg2+) 1.5-2.0 mEq/L Estriol, total, serum (in pregnancy) 24-28 wks // 32-36 wks 30-170 ng/mL // 60-280 ng/mL 28-32 wk // 36-40 wks 40-220 ng/mL // 80-350 ng/mL Ferritin, serum Male: 15-200 ng/mLFemale: 12-150 ng/mL Follicle-stimulating hormone, serum/plasma Male: 4-25 mIU/mL Female: premenopause: 4-30 mIU/mL midcycle peak: 10-90 mIU/mL postmenopause: 40-250 pH 7.35-7.45 PCO2 33-45 mmHg PO2 75-105 mmHg Glucose, serum Fasting: 70-110 mg/dL2-h postprandial:<120 mg/dL Growth hormone - arginine stimulation Fasting: <5 ng/mLProvocative stimuli: > 7ng/mL Immunoglobulins, serum IgA 76-390 mg/dL IgE 0-380 IU/mL IgG 650-1500 mg/dL IgM 40-345 mg/dL Iron 50-170 μg/dL Lactate dehydrogenase, serum 45-90 U/L Luteinizing hormone, serum/plasma Male: 6-23 mIU/mL Female: follicular phase: 5-30 mIU/mL midcycle: 75-150 mIU/mL postmenopause 30-200 mIU/mL Osmolality, serum 275-295 mOsmol/kd H2O Parathyroid hormone, serume, N-terminal 230-630 pg/mL Phosphatase (alkaline), serum (p-NPP at 30° C) 20-70 U/L Phosphorus (inorganic), serum 3.0-4.5 mg/dL Prolactin, serum (hPRL) < 20 ng/mL Proteins, serum Total (recumbent) 6.0-7.8 g/dL Albumin 3.5-5.5 g/dL Globulin 2.3-3.5 g/dL Thyroid-stimulating hormone, serum or plasma .5-5.0 μU/mL Thyroidal iodine (123I) uptake 8%-30% of administered dose/24h Thyroxine (T4), serum 5-12 μg/dL Triglycerides, serum 35-160 mg/dL Triiodothyronine (T3), serum (RIA) 115-190 ng/dL Triiodothyronine (T3) resin uptake 25%-35% Urea nitrogen, serum 7-18 mg/dL Uric acid, serum 3.0-8.2 mg/dL Hematologic Reference Range Bleeding time 2-7 minutes Erythrocyte count Male: 4.3-5.9 million/mm3Female: 3.5-5.5 million mm3 Erythrocyte sedimentation rate (Westergren) Male: 0-15 mm/hFemale: 0-20 mm/h Hematocrit Male: 41%-53%Female: 36%-46% Hemoglobin A1c ≤ 6 % Hemoglobin, blood Male: 13.5-17.5 g/dLFemale: 12.0-16.0 g/dL Hemoglobin, plasma 1-4 mg/dL Leukocyte count and differential Leukocyte count 4,500-11,000/mm3 Segmented neutrophils 54%-62% Bands 3%-5% Eosinophils 1%-3% Basophils 0%-0.75% Lymphocytes 25%-33% Monocytes 3%-7% Mean corpuscular hemoglobin 25.4-34.6 pg/cell Mean corpuscular hemoglobin concentration 31%-36% Hb/cell Mean corpuscular volume 80-100 μm3 Partial thromboplastin time (activated) 25-40 seconds Platelet count 150,000-400,000/mm3 Prothrombin time 11-15 seconds Reticulocyte count 0.5%-1.5% of red cells Thrombin time < 2 seconds deviation from control Volume Plasma Male: 25-43 mL/kgFemale: 28-45 mL/kg Red cell Male: 20-36 mL/kgFemale: 19-31 mL/kg Cerebrospinal Fluid Reference Range Cell count 0-5/mm3 Chloride 118-132 mEq/L Gamma globulin 3%-12% total proteins Glucose 40-70 mg/dL Pressure 70-180 mm H2O Proteins, total < 40 mg/dL Sweat Reference Range Chloride 0-35 mmol/L Urine Calcium 100-300 mg/24 h Chloride Varies with intake Creatinine clearance Male: 97-137 mL/minFemale: 88-128 mL/min Estriol, total (in pregnancy) 30 wks 6-18 mg/24 h 35 wks 9-28 mg/24 h 40 wks 13-42 mg/24 h 17-Hydroxycorticosteroids Male: 3.0-10.0 mg/24 hFemale: 2.0-8.0 mg/24 h 17-Ketosteroids, total Male: 8-20 mg/24 hFemale: 6-15 mg/24 h Osmolality 50-1400 mOsmol/kg H2O Oxalate 8-40 μg/mL Potassium Varies with diet Proteins, total < 150 mg/24 h Sodium Varies with diet Uric acid Varies with diet Body Mass Index (BMI) Adult: 19-25 kg/m2 Calculator ( ) xy AC 7 8 9 ÷ 4 5 6 × 1 2 3 - 0 . = + Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK You have 100% on this question. Just skip this one for now. Take This Question Anyway (M2.OR.16.4686) A healthy 28-year-old woman at 30-weeks gestational age, has gained 35lbs since becoming pregnant. She complains of several weeks of bilateral numbness and tingling of her palms, thumbs, index and middle fingers that is worse at night. She also notes weakness gripping objects at the office. Which nerve is most likely affected? Review Topic | Tested Concept QID: 107449 Type & Select Correct Answer 1 Median nerve 100% (2/2) 2 Ulnar nerve 0% (0/2) 3 Radial nerve 0% (0/2) 4 Axillary nerve 0% (0/2) 5 Anterior interosseous nerve 0% (0/2) L 2 Question Complexity C Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 1
All Videos (2) Podcasts (0) Login to View Community Videos Login to View Community Videos Carpal Tunnel Release Surgery Colin Woon Orthopedics - Carpal Tunnel Syndrome 11/23/2012 56 views (1) Login to View Community Videos Login to View Community Videos Durkan's compression test Derek Moore Orthopedics - Carpal Tunnel Syndrome 9/1/2012 27 views (0)