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A 6-year-old boy is admitted with a one-week history of diarrhea, which was sometimes bloody and originally began after a birthday party. He has become lethargic and has not been eating or drinking. His vital signs are as follows: T 38.5 C, HR 135, BP 82/54. Physical examination is significant for petechiae on his legs and diffuse abdominal tenderness to palpation. Lab-work shows BUN 72 mg/dL, creatinine 8.1 mg/dL, and platelet count < 10,000. PT and PTT are within normal limits. Which of the following would be expected on a peripheral blood smear?
Fragmented red blood cells
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A 6-year-old male presents to the emergency room complaining of severe abdominal pain. His mother notes that he has had several episodes of diarrhea for the past week, with vomiting over the past 3 days. The child is on summer vacation and attended a 4th of July barbecue 1 week ago. The patient's vital signs are as follows: T 38.3 C, HR 116, BP 110/75, SpO2 98%. Physical exam is remarkable for diffuse abdominal tenderness without rebound or guarding. CBC shows WBC 9 x10^3/uL, Hgb 10.2 g/dL, Hct 33%, Plt 46 x10^3/uL. Peripheral blood smear yields the following findings (Figure A). The patient's creatinine is found to be elevated at 1.3. What is the underlying cause of this patient's anemia?
Chronic renal disorder
Gastrointestinal arterio-venous malformation
Poor dietary nutrition intake
Inheritance of a beta-globin gene variant
Toxin-mediated damage to endothelial cells and prothrombotic changes