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A 63-year-old female complains of weakness, light-headedness, palpitations, and soreness of the tongue. She has a past medical history of Hashimoto’s thyroiditis. Her hematocrit is 29%. On peripheral blood smear, you notice neutrophils with 7 lobes and large oval-shaped red blood cells. On physical exam, you notice the patient has decreased position sense and a loss in vibratory sensation in her lower extremities. Which of the following is most likely present in this patient?
Atrophy of G cells
Anti-intrinsic factor antibodies
Decreased methylmalonic acid levels
B12 malabsorption due to Diphyllobothrium latum
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A 51-year-old white female presents to her primary care physician for a regular check-up. She endorses eating a healthy diet with a balance of meat and vegetables. She also states that she has a glass of wine each night with dinner. As part of the evaluation, a complete blood count and blood smear were performed and are remarkable for: Hemoglobin 8.7 g/dL, Hematocrit 27%, MCV 111 fL, and a smear showing macrocytes and several hypersegmented neutrophils. Suspecting an autoimmune condition with anti-intrinsic factor antibodies, what other finding might you expect in this patient?
High serum TSH
A 29-year-old woman presents to her primary care physician with worsening fatigue and lightheadedness over the past several months. She states that she has felt easily fatigued and has experienced several falls during this time frame as well. She drinks 5 to 8 drinks per day and works as a waitress. Her temperature is 98.2°F (36.8°C), blood pressure is 114/64 mmHg, pulse is 98/min, respirations are 12/min, and oxygen saturation is 98% on room air. Laboratory studies are ordered as seen below.Hemoglobin: 9.0 g/dLHematocrit: 29%Leukocyte count: 6,700/mm^3 with normal differentialPlatelet count: 199,400/mm^3Methylymalonic acid: 1.0 umol/L (normal < 0.40 umol/L)Which of the following is the most likely etiology of this patient's symptoms?
Vitamin B12 deficiency