Kwashiorkor Causes protein deficient diet Symptoms skin lesions "flaky paint" skin, dry peeling skin with confluent areas of hyperkeratosis and hyperpigmentation pitting edema ↓ albumin leads to ↓ oncotic pressure in vasculature and loss of fluid into extravascular space ascities liver malfunction fatty change due to ↓ apolipoprotein synthesis inability to release fatty acids into circulation inability to process incoming lipids liver cannot distribute fatty acids in liver immune defects in: cell-mediated immunity ↓ in complement protein synthesis phagocyte function IgA antibody concentration cytokine production muscle protein relatively unchanged hematologic defects anemia Marasmus Causes protein and caloric deficient diet Symptoms tissue and muscle wasting "broomstick" extremities breakdown of muscle protein for energy loss of subcutaneous fat variable edema