Deficiency Causes excess zinc elevated levels of zinc induce increased expression of metallothionein login to view 3 more bullets Symptoms a function of what enzymes require copper ferroxidase login to view 2 more bullets lysyl oxidase login to view 3 more bullets Disorders in copper handling Wilson's disease Menke’s disease X-linked gene mutation in ATP7A login to view 1 more bullet aka Ehlers-Danlos syndrome type IX inability of enterocytes to release absorbed copper copper at toxic levels in small intestine and kidneys copper in circulation and in brain at low levels symptoms login to view 5 more bullets