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Updated: Apr 4 2021

Vitamin K

  • Deficiency
    • Causes
      • fat malabsorption
      • neonates have sterile intestines and are unable to synthesize vitamin K
        • aggravated by mothers who took anticonvulsants during pregnancy
        • neonates are given vitamin K injection at birth to prevent hemorrhage
          • newborns are unable to produce enough vitamin K due to a sterile gut
      • can also occur after prolonged use of broad-spectrum antibiotics
        • destruction of normal gut flora
      • ↓ in hepatic function can ↓ vitamin K activation
    • Presentation
      • ↑ PT and ↑ aPTT but normal bleeding time
        • easy bruising, bleeding
        • hemorrhagic disease of the newborn
  • Excess
    • Presentation
      • hemolytic anemia and jaundice
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