Snapshot A 24-year-old female presents with worsening headache, fever, and double vision. Her headache is located in the periorbital region. Medical history is significant for a left-sided mid-facial furuncle which she attempted to squeeze over one week prior. On physical exam, there is bilateral supraorbital edema, lateral gaze palsy, ptosis, mydriasis, and chemosis. Introduction Thombosis of the cavernous sinus Most commonly caused by a continguously spreading infection via valveless venous vessels login to view 6 more bullets Causative organisms are most commonly Staphylococcus aureus (70%) login to view 5 more bullets Epidemiology Mortality < 30% with antibiotic administration Complete recovery is rate Can affect all ages Presentation Symptoms login to view 3 more bullets Physical symptoms login to view 2 more bullets Evaluation Clinical diagnosis Complete blood count login to view 2 more bullets Blood culture CT and MRI with contrast login to view 4 more bullets Differential Angle-closure glaucoma Orbital and periorbital infection Subarachnoid hemorrhage Treatment Broad-spectrum intravenous (IV) antibiotics login to view 1 more bullet Heparin login to view 3 more bullets Corticosteroids login to view 3 more bullets Prognosis, Prevention, and Complications Prognosis login to view 1 more bullet