Overview Snapshot A 73-year-old man presents with fatigue. He reports having difficulty with activities of daily living. He states that his wife notes he is not swinging his arms as much as he used to when walking. On physical examination, a tremor is noted at rest, that improves with purposeful movement. He also walks with a stooped posture during gait testing. He is eventually started on levodopa and carbidopa. Introduction ↑ L-DOPA catecholamine precursor medications login to view 15 more bullets Dopamine receptor agonists bromocriptine (ergot alkaloid) pramipexole and ropinirole (non-ergot) login to view 1 more bullet ↑ Dopamine availability amantadine login to view 7 more bullets Preventing dopamine metabolism monoamine oxidase type B inhibitors login to view 4 more bullets catechol-O-methyltransferase (COMT) inhibitors login to view 4 more bullets Anticholinergics under normal conditions, dopamine and acetylcholine are in electrochemical balance in the basal ganglia login to view 2 more bullets medications login to view 2 more bullets