Snapshot A 58-year-old male is brought to the physician by his daughter for "strange" behavior. He has been innapropriately making sexual remarks, invading people's personal space, and urinating in public. She has noticed that he has been binge eating sweets as of late. His manners and social abilities have drastically worsened. On physical exam, there is a deficit in executive functioning and working memory. Visuospatial function is intact. Introduction Neurodegenerative disorder affecting the frontal and/or temporal lobes login to view 3 more bullets There are different variants login to view 2 more bullets Pick bodies login to view 2 more bullets Presentation Behavioral variant login to view 5 more bullets Primary progressive aphasia login to view 1 more bullet Memory deficits present later Visuospatial function is usually intact Primitive reflexes login to view 1 more bullet Evaluation Clinical diagnosis Histologic findings login to view 3 more bullets MRI login to view 1 more bullet Differential Alzheimer's disease Parkinson's disease Huntington's disease Treatment No medications have been shown to be disease modifying login to view 2 more bullets Prognosis, Prevention, Complications Prognosis login to view 3 more bullets