Snapshot A 68-year-old man is brought to his primary care provider by his daughter after getting lost while going to the grocery store by himself earlier in the week. This was the second time that he has gotten lost. She has also noticed that he is having difficulty remembering what was told to him. She has noticed him having trouble with memory for the past year and, until recently, has been unable to safely care for himself. He can no longer cook dinner because he frequently forgets to turn off the stove. He is otherwise healthy. Physical examination is normal. Laboratory testing is unremarkable. A Montreal Cognitive Assessment is 20 out of 30. Introduction Definition login to view 6 more bullets Associated conditions login to view 2 more bullets Epidemiology Incidence login to view 1 more bullet Risk factors login to view 3 more bullets Etiology Sporadic (in 95% of cases) Apolipoprotein E (APOE) genotype login to view 2 more bullets Presenilin-1 (chromosome 14) and presenilin-2 (chromosome 1) login to view 1 more bullet Pathogenesis The cause is unclear; however, histopathology demonstrates login to view 4 more bullets Gross pathology login to view 2 more bullets Presentation Symptoms login to view 8 more bullets Imaging MRI brain login to view 2 more bullets Studies A clinical diagnosis login to view 4 more bullets Differential Normal pressure hydrocephalus login to view 4 more bullets Vascular dementia login to view 2 more bullets Creutzfeldt-Jakob disease login to view 3 more bullets Normal aging login to view 4 more bullets Dementia with Lewy bodies login to view 6 more bullets Frontotemporal dementia login to view 3 more bullets Treatment Medical login to view 12 more bullets Complications Difficulty with eating or refusal to eat Infection