Snapshot A 61-year-old man presents to his neurologist for weakness. He reports that he has weakness with getting up from a chair or climbing the stairs. He also says that he has been having a lot of dry mouth lately, requiring him to frequently drink water. He smokes 1 pack of cigarettes daily for the past 35 years. Physical examination is notable for proximal upper and lower extremity weakness. There is also recovery of his patellar reflexes with brief and vigorous muscle contraction. Serum studies are notable for autoantibodies against voltage-gated calcium channels. Introduction Definition login to view 1 more bullet Associated conditions login to view 1 more bullet Etiology Paraneoplastic or nonparaneoplastic phenomenon Pathogenesis Autoantibodies directed against presynaptic voltage-gated calcium channels login to view 2 more bullets Presentation Symptoms/physical exam login to view 6 more bullets Studies Making the diagnosis login to view 1 more bullet Electromyography login to view 3 more bullets Serum login to view 2 more bullets Differential Myasthenia gravis login to view 2 more bullets Treatment If Lambert-Eaton syndrome is secondary to small cell lung cancer, then addressing the malignancy will improve symptoms Medical login to view 3 more bullets Prognosis Addressing the underlying cancer will typically improve symptoms