Snapshot A 12-year-old Swedish boy presents to the emergency room for jaundice. He is recovering from a recent upper respiratory infection. He has a history of jaundice as a neonate but no other significant past medical history. On physical exam, he is noted to have splenomegaly and to be mildly jaundiced. Right upper quadrant ultrasound shows gallstones present. Suspicious for a familial hemolytic disorder, the physician orders an osmotic fragility test, which comes back as abnormal. Introduction Overview login to view 2 more bullets Epidemiology Incidence login to view 1 more bullet Genetics login to view 5 more bullets ETIOLOGY Pathogenesis login to view 3 more bullets Presentation History login to view 2 more bullets Symptoms login to view 6 more bullets Physical exam login to view 6 more bullets Studies Osmotic fragility test or acidified glycerol lysis test login to view 1 more bullet Serum labs login to view 4 more bullets Peripheral blood smear login to view 1 more bullet Differential Autoimmune hemolysis login to view 2 more bullets Gilbert syndrome login to view 3 more bullets Treatment Medical login to view 7 more bullets Surgical login to view 5 more bullets Complications Parvovirus B19-induced aplastic crisis Cholecystitis Megaloblastic crisis login to view 1 more bullet