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A 44-year-old obese African-American male presents to clinic with complaints of 3 days of fatigue and dark urine. He has had several similar episodes since birth, all of which resolved spontaneously. He has a 5-year history of poorly controlled type II diabetes mellitus and was started on glipizide one week ago. Prior to the episode, he felt well without any upper respiratory or gastrointestinal symptoms. He predominantly eats fast food, although he tried a new Lebanese restaurant about one month ago. Which of the following is the most likely cause of this patient's symptoms?
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A 5-year-old African American boy is brought into the emergency department by his mother. The mother states that the boy was diagnosed with a urinary tract infection by his PCP and provided with medications a few days ago. Today, he started having abdominal pain and shortness of breath. On exam, the patient has normal vitals, but has mild jaundice and states that he is short of breath. His mother states that her brother had had a similar episode when he was treated for malaria. The child's CBC is significant for a hemoglobin of 8.7 and his MCV is 90. Figure A shows the peripheral smear. Coombs test is negative. What is the most likely diagnosis?
Iron deficiency anemia
Autoimmune hemolytic anemia
Sickle cell anemia