Snapshot A 56-year-old man presents to his annual physical exam with weight loss, fatigue, and weakness. He is a long-term smoker and also recently immigrated from Southeast Asia. He complains of a chronic cough for the past year with occasional bloody mucus. He agrees to undergo imaging for lung lesions and a blood test for tuberculosis. Iron studies reveal decreased serum iron, increased ferritin, and decreased TIBC. Peripheral blood smear shows basophilic stippling. Introduction Anemia of chronic disease resulting from decreased red blood cell production is a login to view 1 more bullet Associated conditions login to view 5 more bullets etiology Pathogenesis login to view 4 more bullets Presentation Symptoms of anemia login to view 4 more bullets Physical exam login to view 2 more bullets Evaluation Labs login to view 4 more bullets Peripheral blood smears login to view 4 more bullets Differential Diagnosis Anemia of renal disease Iron deficiency anemia Aplastic anemia Treatment Treat underlying disease If underlying disease is unknown or treatment of underlying disease does not improve symptomatic anemia login to view 4 more bullets Complications Severe anemia Prognosis Varied based on underlying inflammatory condition