Pralidoxime is a medication used in the management and treatment of organophosphate poisoning. It is in the oxime class of drugs. This activity outlines the indications, action, and administration of pralidoxime therapy as a valuable agent in managing the toxicity of organophosphate-based pesticides and nerve agents. This activity will highlight the mechanism of action, adverse event profile, and other key factors pertinent to members of the interprofessional team in the care of patients with organophosphate poisoning.