Snapshot A 66-year-old man presents to his primary care physician with oral lesions. He is not sure when his symptoms began, but he denies any trauma to his oral mucosa. He endorses smoking 1 pack of cigarettes daily for the past 45 years and drinks socially. Physical examination is notable for white plaques in the oral mucosa that do not scrape off. He is referred for biopsy. Introduction Overview login to view 1 more bullet Associated conditions login to view 1 more bullet Epidemiology Risk factors login to view 3 more bullets ETIOLOGY Pathophysiology login to view 1 more bullet Presentation Physical exam login to view 1 more bullet Studies Biopsy login to view 2 more bullets Differential Oral hairy leukplakia login to view 2 more bullets Pseudomembranous candidiasis login to view 2 more bullets Treatment Conservative and lifestyle login to view 6 more bullets Surgical and interventional login to view 3 more bullets Complications Recurrence Squamous cell carcinoma Prognosis May recur or progress to squamous cell carcinoma desipite surgical removal