Oncology Drug Introduction Oncology medications can be broken down into the following categories alkylating agents antimetabolites microtubule inhibitors topoisomerase inhibitors antibiotics immunomodulators Oncology Drug Table Alkylating Agents Name Mechanism of Action Key Indication Key Toxicity Busulfan Cross links DNA CML Bone marrow ablation Pulmonary fibrosis Bone marrow suppression Carboplatin Cisplatin Oxaliplatin Cross links DNA Testicular cancer Ovarian cancer Bladder cancer Lung cancer Ototoxicity Nephrotoxicity Peripheral neuropathy Cyclophosphamide DNA cross linkage at guanine residues Leukemia Lymphoma Solid tumors Myelosuppression Hemorrhagic cystitis (prophylaxis with mesna) Chlorambucil Inhibits DNA replication Causes DNA damage CLL Myelosuppression Antimetabolites Name Mechanism of Action Key Indication Key Toxicity Methotrexate Dihydrofolate reductase competitive inhibitor Leukemia Lymphoma Sarcoma Ectopic pregnancy Abortion Psoriasis Rheumatoid arthritis Myelosuppression (reverse with leucovorin) Megaloblastic anemia (prevent with folate) Mucositis/stomatitis Cytarabine Pyrimidine analogue Leukemia Lymphoma Pancytopenia Fludarabine Purine analogue Leukemia Lymphoma Lymphopenia Infection 6-Mercaptopurine Purine analogue Immunosuppressant Inflammatory bowel disease SLR Myelosupppression 5-Fluorouracil Pyrimidine analogue Colon cancer Basal cell carcinoma Pancreatic cancer Myelosupppression Microtubule Inhibitors Name Mechanism of Action Key Indication Key Toxicity Vinblastine Microtubule inhibitor Lymphoma Leukemia Solid tumors Peripheral neuropathy Neurotoxic Vincristine Microtubule inhibitor Lymphoma Leukemia Solid tumors GI problems Hair loss Peripheral neuropathy Topoisomerase Inhibitors Name Mechanism of Action Key Indication Key Toxicity Irinotecan DNA topoisomerase inhibitor Colon cancer Ovarian cancer Small cell lung cancer Myelosuppression Antibiotics Name Mechanism of Action Key Indication Key Toxicity Bleomycin Free radical DNA damage Hodgkin lymphoma Testicular cancer Pulmonary fibrosis Myelosuppression Dactinomycin (actinomycin D) Intercalates between DNA base pairs Ewing sarcoma Wilms tumor Rhabdomyosarcoma Myelosuppression Doxorubicin Free radical damage Intercalates between DNA base pairs Leukemia Lymphoma Cardiotoxicity Mitomycin DNA-cross linkage Adenocarcinoma of the stomach, pancreas Myelosuppression Nephrotoxic Pulmonary toxicity Cardiotoxicity Immunomodulators Name Mechanism of Action Key Indication Key Toxicity Interferon IFN-α analogue Cancer Viral infections (Hep B/C) Flu-like syndromes
QUESTIONS 1 of 10 1 2 3 4 5 6 7 8 9 10 Previous Next Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK (M2.PH.16.4671) A 32-year-old male patient presents to your clinic with nontender unilateral testicular swelling which was first noted by his partner one week ago. After extensive workup and orchiectomy, the patient is diagnosed with testicular seminoma stage IIB. The patient undergoes three cycles of etoposide, bleomycin and cisplatin. In addition, the patient also decides to supplement his treatment regimen with vitamin D and garlic based upon his readings on the internet. Four months later, the patient develops a nonproductive cough, shortness of breath with exertion, and occasional fever. A chest x-ray is shown (Figure A). What is the likely cause for the patient’s current symptoms? QID: 107171 FIGURES: A Type & Select Correct Answer 1 Etoposide 4% (1/23) 2 Bleomycin 74% (17/23) 3 Cisplatin 9% (2/23) 4 Vitamin D 4% (1/23) 5 Garlic 0% (0/23) M 7 Question Complexity E Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 2 Review Tested Concept Review Full Topic (M3.HE.15.55) A 64-year-old woman presents to her primary care physician with complaints of fatigue, a sore mouth, as well as occasional abdominal pain and diarrhea for the past several months. She denies any loss of balance, trouble walking, numbness, pain, or tingling in her hands or feet. She has a past medical history of morbid obesity, depression, rheumatoid arthritis, suicide, anxiety, hypertension, diabetes, and factor V Leiden being managed by her PCP. Her temperature is 99.4°F (37.4°C), blood pressure is 154/94 mmHg, pulse is 87/min, respirations are 18/min, and oxygen saturation is 98% on room air. Physical examination is significant for the finding in Figure A. The patient's creatinine is 2.0 mg/dL at this visit. Which of the following is most likely to be found in this patient? QID: 102684 FIGURES: A Type & Select Correct Answer 1 Aplastic anemia 5% (1/22) 2 Hemolytic anemia 0% (0/22) 3 Megaloblastic anemia 9% (2/22) 4 Microcytic anemia 9% (2/22) 5 Polycythemia 73% (16/22) M 10 Question Complexity E Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 3 Review Tested Concept Review Full Topic Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK (M3.ON.12.23) A 51-year-old woman presents to your office with 2 weeks of fatigue and generalized weakness. She has a past medical history of diabetes, hypertension, and hyperlipidemia. She was recently diagnosed with rheumatoid arthritis and started on disease-modifying therapy. She states she has felt less able to do things she enjoys and feels guilty she can't play sports with her children. Review of systems is notable for the patient occasionally seeing a small amount of bright red blood on the toilet paper. Laboratory studies are ordered as seen below.Hemoglobin: 12 g/dLHematocrit: 36%Leukocyte count: 7,700/mm^3 with normal differentialPlatelet count: 207,000/mm^3MCV: 110 fLWhich of the following is the most likely etiology of this patient's fatigue? QID: 102777 Type & Select Correct Answer 1 Depression 0% (0/6) 2 Gastrointestinal bleed 17% (1/6) 3 Iron deficiency 0% (0/6) 4 Medication side effect 50% (3/6) 5 Vitamin B12 deficiency 33% (2/6) M 10 Question Complexity E Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 4 Review Tested Concept Review Full Topic Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK
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