Review Question - QID 214449

A 43-year-old woman with a 10 pack-year smoking history is diagnosed with estrogen and progesterone receptor-positive, Her2-negative invasive ductal carcinoma of the left breast. She undergoes induction chemotherapy with doxorubicin, methotrexate, and cyclophosphamide that is to be followed by radiation and hormonal therapy. Preoperative echocardiography revealed normal biventricular function, while preoperative serum electrolytes and blood counts were within normal limits. On the third day of chemotherapy infusion, the patient reports painless bloody urine in the morning that has not abated. Which of the following could have decreased the risk of this presentation?