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QID: 109466
A 75-year-old man with coronary artery disease and mitral valve stenosis status-post coronary artery bypass graft and mitral bioprosthetic valve replacement is evaluated in the intensive care unit. His postsurgical course was complicated by ventilator-associated pneumonia and bilateral postoperative pleural effusions requiring chest tubes. He has been weaned from the ventilator and has had his chest tubes removed but has required frequent suctioning to minimize aspirations. He has been dependent on a percutaneous gastrostomy tube for enteral nutrition for the past four weeks. He is currently on aspirin, carvedilol, atorvastatin, ceftazidime, and pantoprazole. He has a history of prostate cancer status post radical prostatectomy. His temperature is 96°F (35.6°C), blood pressure is 95/55 mmHg, pulse is 50/min, and respirations are 20/min. On physical exam, he is not alert and oriented but responds with moans when stimulated. His laboratory data are listed below: Serum: Na+: 145 mEq/L Cl-: 110 mEq/L K+: 3.4 mEq/L HCO3-: 26 mEq/L BUN: 10 mg/dL Glucose: 112 mg/dL Creatinine: 1.4 mg/dL Thyroid-stimulating hormone: 10 µU/mL Ca2+: 11.1 mg/dL PO4-: 1.0 mg/dL AST: 6 U/L ALT: 10 U/L Albumin: 2.5 mg/dL Lactate dehydrogenase: 200 U/L (140-280 U/L) Haptoglobin: 150 mg/dL (30-200 mg/dL) 1,25-(OH)2 D3: 10 pg/mL (15-75 pg/mL) Parathyroid hormone: 9 pg/mL (10-60 pg/mL) Leukocyte count: 10,000 cells/mm^3 with normal differential Hemoglobin: 9 g/dL Hematocrit: 30 % Platelet count: 165,000 /mm^3 His electrocardiogram and chest radiograph are shown in Figures A and B. What is the most likely cause of his hypercalcemia?
  • Renal
  • - Electrolyte Disturbances
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