Overview Snapshot A 22-year-old female presents with left-sided, throbbing headache that worsens when lifting groceries or climbing the stairs. Going to a quiet, dark room improves her symptoms. She has tried over-the-counter non-steroidal anti-inflammatory (NSAID) medications and acetaminophen, which provided no relief. Introduction Role of serotonin in migraine headaches login to view 2 more bullets Mechanism 5-HT1B/1D agonist login to view 5 more bullets Clinical use login to view 6 more bullets Toxicity login to view 2 more bullets Etiology of migraine headache is not fully understood serotonin is involved in the pathophysiology of migraine headaches