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Review Question - QID 215125

Disseminated Intravascular Coagulation (DIC) Epidemiology Risk factors QID: 215125 (M2.OMB.1)
In scope icon M 6 A
QID 215125 (Type "215125" in App Search)
A 65-year-old woman presents for evaluation of fatigue. She has a history of lung adenocarcinoma and has undergone 6 cycles of chemotherapy in the last 5 months. For the last 2 weeks, she has experienced exertional dyspnea and generalized malaise. Her temperature is 99.0°F (37.2°C), blood pressure is 97/64 mmHg, pulse is 105/min, and respirations are 18/min. On exam, she is pale appearing with diffuse petechia and gingival bleeding. Laboratory evaluation reveals:

Hemoglobin: 6.7 g/dL
Hematocrit: 20%
Leukocyte count: 10,000/mm^3
Platelet count: 20,000/mm^3
Prothrombin time (PT): 20 seconds
Partial thromboplastin time (PTT): 60 seconds
D-dimer: 2,000 ng/ml
Direct Coombs test: Negative

A peripheral blood smear is performed, as shown in Figure A. Which of the following is the most likely etiology of the patient’s current presentation?
  • A
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  • A