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Review Question - QID 214986

In scope icon M 6 A
QID 214986 (Type "214986" in App Search)
A 15-year-old girl presents for evaluation of amenorrhea. The patient is concerned that she has not yet undergone menarche as her friends already have. She denies abdominal pain, weight loss, or a calorie-restrictive diet. She has no significant past medical history and takes no medications. Her temperature is 98.8°F (37.1°C), blood pressure is 112/68 mmHg, pulse is 71/min, and respirations are 15/min. Physical exam is notable for a non-tender and non-distended abdomen, Tanner stage IV breasts, and absence of pubic or axillary hair. A pelvic exam reveals a short vaginal canal and no cervix. Laboratory studies are notable for:

Serum:
Luteinizing hormone (LH): 155 mIU/mL
Estrogen: 450 pg/mL
Testosterone: 470 ng/dL (normal: 15-70 ng/dL)

A karyotype is shown in Figure A. Which of the following is the most likely diagnosis?
  • A
  • A