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Review Question - QID 214692

Thalassemias Beta Thalassemia Function of beta chain required at six months when switch from fetal y Hgb to adult beta Hgb occurs QID: 214692 (M2.OMB.4697)
In scope icon M 6 A
QID 214692 (Type "214692" in App Search)
A 22-year-old woman presents to her physician for dizziness and fatigue since visiting her family in Morocco 1 month ago. Two weeks after returning from her trip, she developed a urinary tract infection which resolved with a course of antibiotics. She has no history of serious illness and takes no medications. She does not smoke, drink alcohol, or use illicit drugs. Her mother has systemic lupus erythematosus. Her temperature is 98°F (36.6°C), blood pressure is 125/80 mmHg, pulse is 70/min, and respirations are 12/min. On physical exam, she has conjunctival pallor bilaterally. Laboratory studies show:

Hemoglobin: 11 g/dL
Hematocrit: 27.6 %
Red cell distribution width (RDW): 14%
Mean corpuscular volume (MCV(: 72 µm^3
Leukocyte count: 7,000 /mm^3 with normal differential
Platelet count: 200,000 /mm^3

A peripheral blood smear is shown in Figure A. Which of the following is the most likely diagnosis?
  • A
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  • A