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Review Question - QID 214283

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QID 214283 (Type "214283" in App Search)
A 44-year-old man presents with hand swelling and fatigue. He states that he has morning joint stiffness that lasts for nearly 3 hours every day. He has no medical history and takes no medications. His father has a “blood disorder.” Physical examination reveals non-tender subcutaneous nodules on the patient’s forearms and hands, joint tenderness involving the metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints, and splenomegaly. A radiograph shows a slight subluxation of the MCP joints. Labs are obtained with the results shown below:

Hemoglobin: 10.3 g/dL
Leukocyte count: 3100/mm^3
Absolute neutrophil count: 900/µL
Platelet count: 169,000/mm^3

Which of the following is the most likely diagnosis?