Review Question - QID 213862

A 54-year-old man presents to the emergency department with pain in his right calf. He says it started when he woke up this morning. His medical history is significant for hypertension, diabetes mellitus, chronic kidney disease, alcohol abuse, epilepsy, gastroesophageal reflux disease (GERD), and onychomycosis. He takes lisinopril, metformin, sodium valproate, griseofulvin, and calcium carbonate. He states 2 months ago he had total hip replacement surgery for his left hip. He drinks 4-5 beers a night. He denies any other recreational drugs. A physical examination reveals a swollen left lower leg. A compression ultrasound with Doppler of the left leg indicates a deep vein thrombosis. Heparin is started as a bridge to warfarin, which the patient is discharged on. The patient returns to the emergency department 1 week later with a nosebleed that is resistant to pressure and icepacks. His INR is 7.0. Which of the following medications may be responsible for the patient’s current presentation?