Review Question - QID 213795

A 55-year-old woman is seen in the hospital for “yellowing skin.” She is otherwise asymptomatic. The patient has acute myeloid leukemia. She received a round of chemotherapy 10 days ago that included cytarabine and daunorubicin. Four days ago she was given 2 units of red blood cells for a hemoglobin of 6.1 g/dL. Her medications include omeprazole and voriconazole. The patient's temperature is 98.6°F (37.0°C), blood pressure is 110/73 mmHg, pulse is 78/min, and respirations are 13/min. On examination, the patient is alert and oriented. She has jaundice and her sclerae are icteric. Labs are obtained, as shown below:

Hemoglobin: 6.9 g/dL
Leukocyte count: 440 cells/mm^3 with normal differential
Platelet count: 100,000/mm^3

Total bilirubin: 17.6 mg/dL
Direct bilirubin: 0.5 mg/dL

Which of the following is the most likely cause of the patient’s presentation?