Review Question - QID 213593

A 23-year-old woman presents to the emergency department following a motor vehicle accident. The emergency medical technician reports extensive blood loss. The patient’s husband is with her and describes her medical history. He states that the patient has eczema, gets recurrent sinus infections, and has chronic diarrhea. She experienced a 10-lb weight loss over the past few months. Work-up by her primary care physician included a negative stool culture and negative anti-transglutaminase. She takes no medications. The patient is conscious, but examination is limited by pain. There is a large laceration on her right thigh. Focused assessment with sonography is negative. Imaging of the right lower extremity shows no bony defects. Exploration of the wound is negative for nerve or major artery damage. Laceration repair is performed. Labs are drawn, as shown below:

Hemoglobin: 6.7 g/dL
Hematocrit: 27%
Leukocyte count: 6,000 cells/mm^3 with normal differential
Platelet count: 200,000/mm^3

The patient is given a red blood cell transfusion. Immediately after the transfusion, the patient develops dyspnea, urticaria, and hypotension. A chest radiograph is normal. Which of the following is associated with the patient’s clinical presentation?