Review Question - QID 213222

A 63-year-old man presents to the emergency department with periorbital swelling. He states that he was gardening, came inside, looked in the mirror, and then noticed his eyelids were swollen. He denies pain, pruritus, or visual disturbances. He states that he was drinking “a lot of water" to prevent dehydration, because it was hot outside this morning. His medical history is significant for rheumatoid arthritis. He takes methotrexate and acetaminophen as needed. The patient’s temperature is 98°F (36.7°C), blood pressure is 168/108 mmHg, and pulse is 75/min. Physical examination is notable for periorbital edema, hepatomegaly, and bilateral 1+ pitting lower extremity edema. Labs and a urinalysis are obtained, as shown below:

Leukocyte count: 11,000/mm^3
Hemoglobin: 14 g/dL

Serum:
Na: 138 mEq/L
K+: 4.3 mEq/L
Cl-: 104 mEq/L
HCO3-: 25 mEq/L
Urea nitrogen: 26 mg/dL
Creatinine: 1.4 mg/dL
Glucose: 85 mg/dL
Aspartate aminotransferase (AST, GOT): 15 U/L
Alanine aminotransferase (ALT, GPT): 19 U/L
Albumin: 2.0 g/dL

Urine:
Protein: 150 mg/dL
Creatinine: 35 mg/dL

An abdominal ultrasound reveals an enlarged liver with heterogeneous echogenicity and enlarged kidneys with increased echogenicity in the renal parenchyma. A biopsy of the kidney is obtained. Which of the following biopsy findings is associated with the patient’s most likely diagnosis?