Review Question - QID 212685

A 30-year-old woman presents to her primary care physician for evaluation of irregular and heavy periods. She also complains of recent fatigue, joint pain, and constipation. Physical exam is notable for thinning eyebrows and recent weight gain. Her temperature is 98.0°F (36.7°C), blood pressure is 140/90 mmHg, 51/min, and respirations are 19/min.

Laboratory studies reveal the following:

Serum:
Na+: 141 mEq/L
K+: 4.3 mEq/L
Cl-: 102 mEq/L
BUN: 15 mg/dL
Glucose: 115 mg/dL
Creatinine: 1.0 mg/dL
Thyroid-stimulating hormone: 11.2 µU/mL
Total T4: 2 ug/dL
Thyroglobulin antibodies: Positive
Anti-thyroid peroxidase antibodies: Positive

Which of the following is this patient at increased risk of in the future?