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Review Question - QID 212636

Evaluating Diagnostic Tests Sensitivity, Specificity, PPV, NPV Cut-off point may be adjusted to optimize sensitivity and specificity, which are inversely related (cut-off point with decreased sensitivity is associated with increased specificity and vice-versa) QID: 212636 (M2.OMB.18.1)
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QID 212636 (Type "212636" in App Search)
A study is being conducted to investigate a new diagnostic test for urinary tract infections caused by Staphylococcus saprophyticus. The test looks for the presence of a surface antigen associated with the pathogen. The study took place at a primary care clinic and included 2,340 participants. Urine samples were collected to quantify the concentration of the antigen. Urine cultures were used for the gold standard to diagnosis a urinary tract infection with S. saprophyticus. The results are shown in Figure A. The investigators identified point A as a cutoff for the test. If the cutoff value is instead shifted to point B, which of the following would occur?
  • A
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  • A