Review Question - QID 212566

A 27-year-old man presents to the emergency department due to a change in his skin color. The patient went on a long hike this morning, and his girlfriend noticed that his skin had changed color when they were driving home. The patient has a past medical history of marijuana use, IV drug use, alcohol use, and asthma. His current medications include albuterol, fluticasone, and ibuprofen. His temperature is 97.5°F (36.4°C), blood pressure is 120/75 mmHg, pulse is 60/min, respirations are 10/min, and oxygen saturation is 98% on room air. Laboratory studies are ordered and are seen below.

Hemoglobin: 10 g/dL
Hematocrit: 32%
Leukocyte count: 5,500 cells/mm^3 with normal differential
Platelet count: 207,000/mm^3

Serum:
Na+: 139 mEq/L
Cl-: 99 mEq/L
K+: 4.3 mEq/L
HCO3-: 24 mEq/L
BUN: 17 mg/dL
Glucose: 89 mg/dL
Creatinine: 1.0 mg/dL
Ca2+: 10.1 mg/dL
Bilirubin, total: 11.3 mg/dL
Bilirubin, direct: 7.8 mg/dL

Physical exam is notable for a patient with skin that appears yellow/orange. Cardiac, pulmonary, abdominal, and neurological exams are within normal limits. Which of the following is associated with this patient's underlying pathology?