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Review Question - QID 210939

QID 210939 (Type "210939" in App Search)
A cross-sectional study is investigating the association between smoking and the presence of the Raynaud phenomenon in adults presenting to a primary care clinic in a major city. A standardized 3-question survey that assesses symptoms of the Raynaud phenomenon was used to clinically diagnose patients if they answered positively to all 3 questions. Sociodemographics, health-related information, and smoking history were collected by trained interviewers. Subjects were grouped by their reported tobacco use: non-smokers, less than 1 pack per day (PPD), between 1-2 PPD, and over 2 PPD. The results were adjusted for gender, age, education, and alcohol consumption. The adjusted odds ratios (OR) were as follows:

Non-smoker: OR = reference
<1 PPD: OR = 1.49 [95% confidence interval (CI), 1.24-1.79]
1-2 PPD: OR = 1.91 [95% CI, 1.72-2.12]
>2 PPD: OR = 2.21 [95% CI, 2.14-2.37]

Which of the following is represented in this study and suggests a potential causal relationship between smoking and Raynaud phenomenon?