Review Question - QID 210478

A 55-year-old woman with no significant medical history presents to her primary care doctor with fever, fatigue, and bleeding gums for the past 3 days. She denies any sick contacts. Her temperature is 101°F (38.3°C), blood pressure is 110/70 mmHg, pulse is 96/min, and respirations are 15/min. A physical exam reveals several oral mucosal petechiae, bleeding gums, bilateral submandibular lymphadenopathy, and hepatosplenomegaly. Initial laboratory workup shows the following:

Leukocyte count and differential:
Leukocyte count: 6,600/mm^3
Segmented neutrophils: 60%
Bands: 20%
Eosinophils: 9%
Basophils: 1%
Lymphocytes: 0%
Monocytes: 10%
Platelet count: 99,000/mm^3

Hemoglobin: 8.1 g/dL
Hematocrit: 25%

Prothrombin time: 25 sec
Partial thromboplastin time: 50 sec
International normalized ratio: 1.6
D-dimer: 2,000 µg/mL
Fibrinogen: 99 mg/dL

A bone marrow biopsy demonstrates 34% myeloblasts with Auer rods that are myeloperoxidase positive. Which of the following is the most appropriate treatment for this patient?