Review Question - QID 210397

A 67-year-old man presents to the emergency department with a cough and shortness of breath. His symptoms have been gradually worsening, but he woke up in the middle of the night suddenly feeling short of breath. The patient has a medical history of obesity and hypertension which is currently not treated. His temperature is 98.9°F (37.2°C), blood pressure is 187/108 mmHg, pulse is 100/min, respirations are 14/min, and oxygen saturation is 98% on room air. Physical exam demonstrates mild JVD. Mild bibasilar crackles are noted on pulmonary exam. An ECG is obtained without significant findings. Cardiac troponins drawn 3 hours after the patient's presentation come back negative while BIPAP is administered. Echocardiography reveals an ejection fraction of 34%. Currently, the patient states he feels comfortable and is asymptomatic but was very alarmed at his shortness of breath at night. Which of the following is the most effective mortality-lowering agent for this patient?