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Review Question - QID 109653

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QID 109653 (Type "109653" in App Search)
A 20-year-old man presents to the emergency department after he fainted during a competition. This is the 2nd time this has happened since the patient joined the track team. The patient has a medical history of multiple episodes of streptococcal pharyngitis which were not treated in his youth. He is not currently on any medications. He is agreeable and not currently in any distress. His temperature is 99.5°F (37.5°C), blood pressure is 132/68 mmHg, pulse is 90/min, respirations are 12/min, and oxygen saturation is 98% on room air. The patient is in no current distress. A neurological exam is within normal limits. A pulmonary exam reveals clear air movement bilaterally. A cardiac exam reveals a systolic murmur best heard at the lower left sternal border. Abdominal exam reveals a soft abdomen that is non-tender in all 4 quadrants. The patient's cardiac exam is repeated while he squats. Which of the following is the most likely result for this patient?

Decreased murmur in hypertrophic obstructive cardiomyopathy

71%

5/7

Decreased murmur in mitral stenosis

14%

1/7

Increased murmur in aortic stenosis

14%

1/7

Increased murmur in hypertrophic obstructive cardiomyopathy

0%

0/7

Increased murmur in mitral stenosis

0%

0/7

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This patient is presenting with syncope upon exertion and a murmur that suggests a diagnosis of hypertrophic obstructive cardiomyopathy (HOCM). The murmur of HOCM is reduced with squatting.

HOCM classically presents with syncope upon exertion in a young patient. Though sudden death is a possible complication, this is a less common presentation than syncope. When a patient squats, preload and afterload are increased. The increase in preload increases the volume of blood in the heart. Similarly, the increase in afterload decreases the ejection fraction thus increasing the volume of blood in the heart. In HOCM, the increase in the volume of the cardiac chambers decreases outflow obstruction thus reducing the murmur. Treatment is with beta-blockers, lifestyle changes, and possible defibrillator implantation.

Naik and Shah review the evidence regarding heart murmurs in teenagers. They discuss how multiple benign and pathologic etiologies may all be responsible for a new onset murmur. They recommend making an accurate diagnosis in order to reduce morbidity.

Incorrect Answers:
Answers 2 & 5: Increased/decreased murmurs in mitral stenosis are the incorrect diagnosis for this patient. Mitral stenosis can occur in the setting of rheumatic fever (possible with this patient's history of Streptococcal pharyngitis) and presents with a mid-diastolic rumbling heard best at the cardiac apex. Treatment is with valve replacement.

Answer 3: Increased murmur in aortic stenosis does describe the change in the murmur that would occur with squatting. However, this patient's age, and classic presentation of syncope in a young athlete is more suggestive of HOCM rather than aortic stenosis. Treatment is with valvuloplasty or valve replacement.

Answer 4: Increased murmur in hypertrophic obstructive cardiomyopathy (HOCM) does not describe the changes that would occur when cardiac chamber volume increases (such as during squatting). This finding would be heard if the patient were asked to stand, or if afterload were decreased (such as administering an ACE inhibitor).

Bullet Summary:
Squatting increases preload and afterload and reduces the murmur heard in HOCM.

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