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Review Question - QID 109594

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QID 109594 (Type "109594" in App Search)
A 37-year-old Mexican man presents to his neurologist for new onset seizures. The patient began having seizures one week ago just prior to when he immigrated to the United States. The patient otherwise has a past medical history of two emergency department admissions for substance detoxification. His current medications include ginkgo biloba. His temperature is 99.5°F (37.5°C), blood pressure is 160/105 mmHg, pulse is 90/min, respirations are 15/min, and oxygen saturation is 98% on room air. On physical exam, you note an obese man who appears to be in no distress. Cardiopulmonary exam is within normal limits. Neurological exam reveals cranial nerves II-XII as grossly intact with 5/5 strength in the upper and lower extremities. That patient's gait is stable, and his Romberg sign is negative. A MRI is performed as seen in Figure A. Which of the following is the next best step in management?
  • A

Ceftriaxone and vancomycin

4%

3/73

Neurosurgical evacuation/excision

10%

7/73

Lorazepam

3%

2/73

Albendazole

81%

59/73

Detoxification

1%

1/73

  • A

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This patient is presenting with new onset seizures in the setting of a head MRI demonstrating multiple fluid-filled cysts suggesting a diagnosis of neurocysticercosis. The best treatment for this pathology is albendazole or praziquantel.

Neurocysticercosis typically occurs in patients who have eaten undercooked meat (typically pork) infected with Taenia solium. Suspect this diagnosis in patients who have new onset neurological symptoms (such as seizures) who have been exposed to questionable meat, or come from a background that could involve poor sanitation/preparation of food (e.g., immigrants from developing countries). Imaging of the head will demonstrate cysts throughout the brain. Treatment should be started with albendazole and praziquantel.

Figure A is a MRI of the head demonstrating the multiple cysts seen in neurocysticercosis.

Incorrect Answers:
Answer 1: Ceftriaxone and vancomycin are appropriate initial antibiotics for bacterial meningitis, which presents with fever, photophobia, and neck stiffness/pain.

Answer 2: Neurosurgical evacuation/excision would not be appropriate management. The cystic lesions are occurring secondary to an infectious process.

Answer 3: Lorazepam is an appropriate initial therapy for patients having seizures (e.g., alcohol withdrawal seizures).

Answer 5: Detoxification is appropriate management if this patient is presenting with acute intoxication; however, his seizures are more likely due to neurocysticercosis based on his MRI.

Bullet Summary:
Neurocysticercosis should be treated with albendazole or praziquantel.

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