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Review Question - QID 109188

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QID 109188 (Type "109188" in App Search)
A 12-year-old boy is brought to his pediatrician by his mother who is concerned about his recent rash. She first noticed some red dots on his skin last week, and they have become more expansive in the last few days. The patient has been eating his normal diet, but he has been chewing more slowly and his gums have begun to bleed after brushing his teeth. He has been sleeping more than usual, though he is otherwise acting like himself. He has not been ill recently or received any vaccines. The boy had an unremarkable birth history and was diagnosed with autism spectrum disorder at age three. He is primarily nonverbal and attends a school for children with special needs. His younger sister has asthma, and his mother has atopic dermatitis. At this visit, the patient’s temperature is 98.2°F (36.8°C), pulse is 85/min, blood pressure is 110/62 mmHg, and respirations are 15/min. Exam reveals a thin boy who avoids eye contact and does not respond to verbal questions. Cardiopulmonary exams are unremarkable. The hair on his arms is particularly coiled. The child’s leg is shown in Figure A, and his gingiva are shown in Figure B. Which of the following is the best next step in management?
  • A
  • B

Call child protective services

10%

1/10

Obtain complete blood count

20%

2/10

Test plasma vitamin C levels

10%

1/10

Admit to hospital for enteral nutrition

0%

0/10

Supplement ascorbic acid

60%

6/10

  • A
  • B

Select Answer to see Preferred Response

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This patient presents with petechiae, gingival hemorrhage, and coiled body hair, most consistent with vitamin C deficiency or scurvy. The best next step in management upon clinical suspicion of scurvy is supplementation with vitamin C.

While vitamin C (ascorbic acid) deficiency is now very rare in the developed world, malnourished patients or those with particular eating habits, such as children with autism spectrum disorder, can be affected. Empiric supplementation with vitamin C is the first-line treatment if scurvy is suspected. Increased intake of citrus fruits, which are high in vitamin C, is also recommended if the patient is able to tolerate them. Resolution of symptoms with increased vitamin C intake confirms the diagnosis.

Figure A shows diffuse petechiae on the leg. Figure B shows gingival hemorrhage.

Incorrect Answers:
Answer 1: Calling child protective services would be warranted if there were suspicion of child abuse. Ecchymoses are more common signs of abuse than petechiae, and although nutritional deficiency is suspected, there is ample reason to believe that this is due to the child’s dietary preferences as opposed to neglect.

Answer 2: Obtaining a complete blood count might be useful if platelet disorders such as immune thrombocytopenia were suspected, as they can also cause diffuse petechiae and bleeding gums. However, this patient’s combination of symptoms (in particular corkscrew hairs) is suggestive of scurvy, and lab testing is not required for diagnosis of this condition.

Answer 3: Testing plasma vitamin C levels is typically not performed for confirmation of scurvy. The diagnosis is primarily made based on clinical presentation, as blood tests often do not correlate well with functional vitamin C status.

Answer 4: Admission to the hospital for enteral nutrition would be required if this patient were suffering from hemodynamic instability or orthostasis due to poor dietary intake. This patient is seemingly able to feed himself but has a specific nutritional deficiency, so general enteral nutrition is not indicated.

Bullet Summary:
Scurvy presents with petechiae, gingival hemorrhage, and corkscrew hairs, and the best initial step in management is supplementation with vitamin C.

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