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Review Question - QID 105664

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QID 105664 (Type "105664" in App Search)
A 25-year-old nulliparous woman presents to the clinic for her first prenatal visit. Which of the following risk factors warrants syphilis screening in this patient?

History of gonococcal urethritis

0%

0/7

History of HIV

29%

2/7

History of abnormal Pap smear

0%

0/7

History of autoimmune disease

0%

0/7

All pregnant women should be screened for syphilis

71%

5/7

Select Answer to see Preferred Response

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All pregnant women should be screened for syphilis, regardless of risk factors.

Congenital syphilis is one of the "ToRCHeS" infections (Toxoplasmosis, Rubella, CMV, HIV, HSV, Syphilis). In neonates, it presents with classic signs such as CN VIII deafness, saddle nose deformity, saber shins, Hutchinson's teeth, and "mulberry" molars. Treatment with penicillin prevents maternal transmission to the fetus and treats fetal infection.

Mattei et al. note that rates of primary and secondary syphilis have increased over the past 10 years, including in women, underscoring the importance of screening in pregnant women.

Wolff et al. reaffirmed the USPSTF recommendations in the Annals of Internal Medicine in 2009, noting that a recent study evaluated the effect before and after the implementation of a universal syphilis screening program for pregnant women and found reductions in rates of congenital syphilis. Furthermore, two additional studies on screening accuracy for syphilis reported false-positive rates of less than 1%.

Illustration A depicts the widely-spaced, notched "Hutchinson's teeth" characteristic of congenital syphilis.

Incorrect Answers:
Answers 1-3: Regardless of risk factors, all pregnant women should be screened for syphilis.
Answer 4: The presence of autoimmune disease may cause a false-positive result on nontreponemal antibody tests such as rapid plasma reagin (RPR).

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