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Review Question - QID 105424

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QID 105424 (Type "105424" in App Search)
A 14-year-old male is brought to an endocrinologist because his parents are concerned he is "too short." His pediatrician is contacted for his medical records, and his growth chart is obtained. If this patient's short stature is secondary to constitutional growth delay, which of the following curves would likely correspond to this presentation?
  • A

A

6%

3/50

B

70%

35/50

C

14%

7/50

D

6%

3/50

Not shown

0%

0/50

  • A

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Curve B corresponds to constitutional growth delay, attaining a normal height by 18 years.

The most common cause of short stature and pubertal delay is constitutional growth delay. This condition has a classic presentation on growth charts: normal birth weight and height, drop in percentiles on growth curve between 6 months and 3 years, re-establishment of normal growth velocity, and following the growth curve at the 5th to 10th percentiles. Adolescents will have a normal growth spurt and normal adult height. Constitutional growth delay is characterized by a bone age that is less than chronological age; the child's short height is often appropriate when assessed in the context of their skeletal age. The only management is reassurance and regular follow-up.

Duck reports on the management of a slow growing child. Children older than three years of age who grow less than 1.75 in (4.5 cm) per year should be evaluated with a thorough family and personal medical history (including prenatal and birth information). Additionally, the work-up should include consideration of chromosomal disorders, systemic diseases, and endocrine dysfunctions. Disproportionate growth of the limbs and trunk is a warning sign of for the presence of a bone or collagen disorder. A prediction of a child's final height may be assisted with a bone age radiograph of the left hand.

Wit et al. discuss the management of idiopathic short stature (ISS). In boys with constitutional growth delay, androgens may increase height and sexual characteristics, but adult height is unchanged. Growth hormone (GH) therapy is effective in increasing height velocity and adult height, but response is variable. In the case of a low predicted adult height at the onset of puberty, administration of a gonadotropin-releasing hormone (GnRH) analogue can be considered for height augmentation.

Figure A displays a growth curve with several causes of short stature.

Incorrect Answers:
Answer 1: Line A corresponds to postnatal onset pathologic short stature.
Answer 3: Line C corresponds to familial short stature.
Answer 4: Line D corresponds to prenatal onset pathologic short stature.
Answer 5: Line E is shown in answer B.

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